Curriculum Vitae Dr. Bencosme PD
PUBLICACIONES REVISTAS INTERNACIONALES:
Studies on the methods of straining the islet cells of the pancreas. Sergio A. Bencosme, Arch. Pathol., 53: 87-97, 1952
Cytological studies of the islets of Langerhans of the pancreas have required the use of many and varied histological techniques.1 Each method has had its advantages and disadvantages, but the most serious deficiencies have been the inexact chromatic specificity and the lack of correlation between the various methods. The relatively small number of cellular structures differentially. studies-on-the-methods-of-staining-the-islet-cells-of-the-pancreas
Histologic Studies of the Internal Mammary Artery after Implantation in the Myocardium. S. A Bencosme and A. Vineberg Am. Heart J., 45: 571, 1953
The Internal mammary artery after implantation into the left ventricular myocardium of the dog develops new branches. These newly developed branches enter the myocardium and form a connection with the left coronary circulation. This fact has been proved by injection studies, serial sections, plastic casts, and physiologic evidence.1,2,3 When a large anastomosis exists between the implanted internal mammary artery and the left coronary circulation—it protects against death and infarction after sudden ligation of the anterior descending branch of the left coronary artery. PDF
A Trichrome Staining method for routine use. S.A. Bencosme. Am J. Pathol., 24: 1324-1954 . Am. J. Clin.Pathol., 24: 1324-1954
Despite the added information obtained from a trichrome stain, no stain has replaced the hematoxylin-eosin method for routine use in the majority of hospital laboratories and university departments of pathology, although many trichromic methods have been published, some expressly- designed for routine purposes. PDF
Citology Of Islet Cells In Alloxan Diabetic Rabbits. Sergio A Bencosme. (1955) amjpathol-cytology-of-islet-cells-in-alloxan
Regional differences of the pancreatic islet. Sergio A. Bencosme and E. Liepa . Endocrinology, 57: 588, 1955 SIMARD (1945) found an almost complete disappearance of the a cell in a subcutaneous pancreatic transplant of one dog which had been operated upon following the method of ivy and Farrell (1926). our interest in the a cell in relation to glucagon led us to investigate the possibilities offered by simard’s work. in the present study we have confirmed simard’s observations that the transplanted segment was devoid of a cells and have concluded that regional differences in islet cell composition were responsible for the absence of a cells in the transplants. PDF
Difficulties in assessing relation in glucagon to alpha cells. S.A Bencosme. Rev. Can.Biol., 14: 175, 1955
In spite of the amount of work done on origin of glucagon, there is no agreement as to the site of its production (1-5). Some investigators found a significant reduction of glucagon in the pancreas of cobalt-treated guinea pigs and dogs(8,9); others found no diminution in glucagon content of cobalt-treated dogs(6,7); while others stated that the glucagon content of cobalt-treated rabbits was twice that of normal(4). However, these workers (4) found no glucagon in the pancreas of synthalin A treated rabbits. PDF
Development and Regression of Cortisone-Induced Lesions in Rabbit Páncreas Sydney S. Lazarus and Sergio A. Bencosme. Am J. Clin Pathol., 26: 1146-1956
This paper deals with a study of the mode of development and regression of the degranulation of B cells, the infiltration of glycogen, and the ductular proliferation in the pancreas of the cortisone-treated rabbit. It was hoped that the results would further elucidate the pathogenesis and significance of these histologic changes. PDF
Influences of Steroids on Carbohydrate Content of Rabbit Kidney:A Chromatographic Study.* S.A. Bencosme, D.A Rosen, D.E Wilson, V.C Runeckles and J. Frei. Proc. Soc. Exp. Bill. Med., 93: 587, 1956
*This work was supported by National Health Grants and by grant from Canadian Life Insurance Officers’ Assn.demonstrate the effects of cortisone acetate,t prednisone. and desoxycorticosterone acetate on concentrations of certain carbohydrates extractable from rabbit kidneys. The sugars studied, rhamnose, mannose. fucose, glucose and galactose, are known to stain with PAS PDF
Changes in dogs devoid A Cells. S.A. Bencosme,S.Mariz and J. Frei. Endocrinology, 61: 1, 1957 16-changes-in-dogs-devoid-of-a-cells
Further Studies on the Relationship of Glucagon to the alpha cells of the Pancreas. S.A Bencosme, S. Mariz and J. Frei. Am J. Clin. Patrol., 28: 594, 1957
The relationship of the morphology of the alpha cell and the amount of glucagon present in the pancreas of dogs and rabbits treated with drugs reputed to be toxic for the alpha cell has been further investigated. A summary is given of several experiments dealing with the lack of alpha cell damage in several species following the administration of drugs reputed to be toxic for the alpha cell. It is concluded that glucagon is produced by the alpha cell of the pancreas, and that much of the confusion on this subject probably, results from a failure to recognize the technical difficulties involved in obtaining accurate morphological definition of the structure of the alpha cell at the time the tissue was excised from the body. PDF
Studies on the Function of the Alpha cells of the Pancreas , 1957. Sergio A. Bencosme, M.D., PhD., S. Mark, M.D., and J. Frei, M.D. studies-on-the-function-of-the-alpha-cells-of-the-pancreas
Glomerular Lesions produced in the Rabbit by Prednisone and Prednisolone S.A Bencosme, D. L. Wilson and D. A. Rosen. A.M.A. Arch. Patrol., 64: 340, 1958 This report deals with experiments carried out using the,synthetic steroids, prednisone and prednisolone)’ These substances are reported to have greater anti-inflammatory activity than cortisone, while exerting negligible effects on carbohydrate or electrolyte balance. PDF
Elastase Activity of the Pancreas and Its Relation to the Alpha Cells. S.A. Bencosme and D.F. Cranston. Lab. Invest 7:201, 1958 The fact that alpha cells are absent in the uncinate process of the dog pancreas, but abundant in the rest of this organ,5 affords an excellent opportunity to investigate the relationship between alpha cells and clastase. Similarly, the selective damage to alpha cells by cobalt chloride and Synthalin A in the guinea pig 3,13 permits one to study the relationship between alpha cells and elastase. The purpose of this work is to correlate the elastase activity of the pancreas with the distribution and morphology of alpha cells. PDF
Electron Microscopy of Pancreatic Islets. S.A Bencosme and D.C. Pease. Endocrinology, 63: 1, 1958 Pancreatic islets have been studied by the electron microscopy of ultrathin sections mature guinea pigs anti cats. Alpha cells contain specific granules which are notably dense after fixation with osmium tetroxide. Their substance is homogeneous. They arc enclosed within a vacuolar membrane. Other organdies such as the Golgi apparatus, endoplasmic reticulum, RNA granules and mitochondria arc present inconspicuously, and without particular specialisation. Beta cells of the cat and guinea pig differ in important respects. In the cat the specific granules contain an angular crystalloid element. The homologous structure in the guinea pig is spherical. These granules are enclosed in membranous envelopes. The density of the granules is substantially less than those of alpha cells. PDF
A rapid Method for localization of tissue structures of Lesions for Electron Microscopy. S.A. Bencosme, R.S. Stone, H. Latta and S.C Madden, Biophysics, Biochem, Cytol., 5: 508, 1959 a-rapid-method-for-localization-cytol-1959-bencosme-508-10
Physiological Function of Alpha Cells of the Pancreas SERGIO A. BENCOSME,JOSE M. TOLEDO AND DENNIS F. CRANSTON,1959 25-physiological-function-of-alpha-cells-of-the-pancreas
Functioning pancreatic Islets cell tutors studied electron microscopically . S.A Bencosme, R.A. Allen and H. Latta. The American Journal of Pathology vol XLII, 1963amjpathol1963-functioning
Immediate and delayed effects of Ionising Radiation on Hepatic Cells Sergio A. Bencosme, V. I. Kalnina and H. F. Stich Fith Internacional Congress for Electron Microscopy, 2: V V-2, 1962inmediate-and-delayed-effects-of-ionizing-radiation-on-hepatic-cells-1962
Kaliopenic Nephropathy: A correlated light and electron microscopy study. C.G. Brava, I. Dyrda, J. Genest and S.A. Bencosme,1963 kaiopenic-nephropathy-sb
Functioning Panreatic Islet Cell Tumors Studied Electron Microscopically. SERCIO A. BENCOSME, M.D., PH.D.,* RAYMOND A. ALLEN, M.D., AND HARISON LATTA, M.D.
From the Departments of Pathology of the University of California Medical Center, Los Angeles, Calif., and Queen’s University, Kingston, Ontario, Canada. JANUARY, I963
Renal hyaline arteriosclerosis. An electron microscopy study. C. G Brava, I. Dyrda, J.Genest and S.A. Bencosme. Am. J Pathol., 44:349, 1964 renal-hyaline-arteriolosclerosis-1964
Fine structure of nucleoli and RNA-containing chromosome regions of salivary gland chromosomes of chironomids and their interrelationship V. I. KALNINS,H’ . F. STICHA,’N D S. A. BENCOSMEDepartments of Biology and Pathology, Queen’s University, Kingston, Ontavio Received May 3, 1964
La Ultraestructura de Las Células Musculares Cardíacas con Referencia Especial a los Gránulos Específicos I.El miocardio de la Rana. Alberto Trillo y Sergio A. Bencosme. Archivos del Instituto de Cardiología de México. Tomo 25, No 6. Nov-Dic, 1965
Estudio-ultraestructural-del-musculo-cardiaco-en-relacion-con-los-granulos-especificos-1966 II. Alberto Trillo, Adolfo Martínez Palomo, Sergio A. Bencosme
Cardioglobulin B Content of the Blood Plasma of Newborn Infants. Sergio A. Bencosme, D.J. Delahaye, J.E. Fay and N. Ozen ,1967 cardioglobulin-b-content-of-the-blood-plasma-of-newborn-infants
Electron microscope observations on Langerhans. cells in the cervix. M. S. YOUNES, .D.*
E. M. ROBERTSON, M.D., F.R.C.O.G. SERGIO A. BENCOSME, M.D., PH.D. Philadelphia, Pennsylvania, and Kingston, Ontario, Canada. 102:397.1968.
Quantitative electron rnieroscopic analysis of the specific granule population of rat atriamb. WILLIAM W. E. CRANG AND SERGIQ A. BENCOSME. Queen’s University and Kingston Geneml Hospital, Kingston, Ontario
Pathogenesis of Bile-Induced Acute Pancreatitis in the Dog. Experiments with Detergents
Peter T. Sum, MD, PhD, Sergio A. Bencosme, MD, PhD and Ivan T. Beck, MD, PhD, FRCP(C), FACP. 1970.
Received August 27, 1968.Correlative Ultrastructural and Electrophysiological Study of the Purkinje System of the heart. S. A. Bencosme, A. Trillo, J. Alanis And D. Benitez, J. J. ELECTROCARDIOLOGY, 2 (1), 27-38, 1969
Rabbit Pancreatic B Cell. MorphologieM and FunctionM Studies during Embryonal and Post-NatM Development* S. A. BENCOSME, M. B. WILSON, H. ALEYASSINE, A. J. de BOLD, and M. L. de BOLD Department of Pathology, Queen’s University and the Kingston General Hospital, Kingston, Ontario, Canada tteeeived: October 22, 1969
Staining Procedures for the endocrine cells of the upper gastrointestinal mucosa: light-electron microscopic correlation for the gastrin-producing. S.A. Bencosme and J. Lechago. J. Clin. Patrol., 26: 427, 1971.
Ultrastructural Changes in B Cells of Pancreatic Islets from Rats with Elevated Levels of Circulating Growth Hormone Secreted by MtT-W15 Tumor Sergio A. Bencosme, M.D., Ph.D., Victor Tsutsumi, M.D., Julio M. Martin, M.D., and Hans K. Akerblom, M.D., Kingston and Toronto. 1971.
staining-procedures-for-the-endocrine-cells-studies-of-the-relationship-between-the-catecholamine-distribution-in-the-atrium-and-the-specific-granules-present-in-atrial-muscle-cells-1973 Adolfo J DeBold y Sergio A.Bencosme.
The Endocrine Cells of the Upper Gut Mucosa in Dogs Juan Lechago and Sergio A. Bencosme. Department of Pathology, Queen’s University and Kingston General Hospital,
Kingston, Ontario, Canada. October 3, 1973
SELECTIVE LIGHT MICROSCOPIC DEMONSTRATION OF THE SPECIFIC GRANULATION OF RAT ATRIAL MYOCARDIUM BY LEAD HAEMATOXYLIN-TARTRAZINE ADOLFO J. DE BOLD and SERCIO A. BENCOSME, Department of Pathology, Queen’s University and the Hotel Dieu and Kingston General Hospitals, Kingston, Ontario, Canada 1975
Atrial Specific Granules of the Heart Light Microscopic Staining and Histochemical Reactions1 A.J. DeBold,J.J Raymond and S.A. Bencosme (1978) atrial-specific-granules-of-the-rat-heart
Intracellular pancreatic B cell serotonin and the dynamic of insulin release. O. M. Pulido, S.A. Bencosme, M.L. de Bold and A.J. de Bold. Diabetología., 15: 197, 1978 intracellular-pancreatic-b-cell-serotonin-and-the-dynamic-of-insulin-release-1978
Demostration of a tryptaminergic mechanism in the rat B Cell O.M. Pulido, A.J. de Bold M.L. de Bold and S.A. Bencosme
Department o Pathology, Queen’s University and Kingston General Hospital, Kingston (Ontario, Canada K7L 3N6), 12 May 1976
Effects of Serotonin and its Antagonists on the First Phase of Insulin Release in Normal and Hypersomatotropic Rats*. Mercedes L. de Bold and S.A. Bencosme Department of Pathology, Queen’s University and the Kingston General Hospital, Kingston, Ontario, Canada
A Histochemical and Ultrastructural Study of Human Breast Carcinomas With a View to Their Classification by Cell of Origin S. A. BENCOSME,~ M. J. RAYMOND,~ R. C. Ross,” B. MOBBS,~ V. T. sutsumi, H.Ortíz, R.Gonzalez and E. Segura. Exp. Mol. Path., 31:236, 1979.
Steroid nefohropathy in the rabbit D. Laurence Wilson, M.D., David A. Rosen, M.D., and Sergio A. Bencosme, M.D., Kingston, Ontario. 11:402, 1962.